CONTROLLED RELEASE 2017-03-29T14:40:38+01:00

Controlled release

In i+Med we are experts in the formulation of biopolymeric devices for the controlled or sustained drug release.

Controlled release

The release mechanism controls the rate at which the active molecules are released from the carrier until they run out. Our technology allows the combination of these factors to get a combined release at different time scales leading to complex release mechanisms.

These systems present significant advantages over conventional pharmacological treatments: greater control of the dose (quantity and frequency), prevent overdoses, increase the effectiveness of the treatment and minimize the side effects result in an improvement of the quality of life of the patient, as well as contribute to the reduction of periods of treatment and monitoring of the patient and the pharmaceutical expenditure.

Biocompatible coatings

This technology is based on the entrapment of the drugs in a polymeric matrix that acts as a carrier, and allows the customization of the release system on the basis of the target application, the needs of the specialist, the patient, the treatment, etc.

i+Med designs and develops a variety of systems by working on:

  • The release mechanism: diffusion, penetration of the solvent/swelling, degradation or erosion of the polymeric matrix, or combined mechanisms.

  • Polymers sensitive to stimuli: changes in pH, osmolarity, temperature, light irradiation, others.

  • Controlled drug release carrier: the selection of the properties of the constituent material of the carrier is a fundamental aspect in the development of this kind of devices. We are able to manipulate these properties to improve the effectiveness of the systems

  • Morphology of the carrier: crosslinked micro or nanogels, micro or nanospheres, vesicles, films, pellets.

  • Properties of the material: molecular weight, crystallinity, monomers composition, functional groups, solubility, hydrophobicity/hydrophilicity, pKa, permeability, porosity, density, morphology, biodegradability, etc.