Patents
At the forefront of pharmaceutical innovations
At i+Med we hold 5 technological patents in the fields of nanotechnology, phytocannabinoids and polymeric coatings.
Our patents
Biocompatible microgels and their applications
PCT/EP2021/083550
Biocompatible microgels comprise a polymeric network, where the polymeric network consists of monomeric units interconnected with each other by means of a crosslinking agent. Such a polymeric network may be obtained by polymerisation in a dispersed medium of a biocompatible vinyl monomer and a crosslinking agent. The microgel may also include biologically active agents. Biocompatible microgels can be used, among other applications, for the transport and dosage of biologically active agents.
Composition from seawater and sub-microparticles with cannabinoids
In aqueous media, methods and uses
PCT/EP2021/083550
The present invention relates to a composition comprising cannabinoid-loaded polymeric sub-microparticles soluble in an aqueous medium comprising a polyelectrolyte complex comprising a positively charged polymer, selected from chitosan or a derivative thereof, a negatively charged polymer selected from hyaluronic acid or a derivative thereof, and a cannabinoid or a derivative thereof, or a mixture of cannabinoids or derivatives thereof, and water, wherein the size of the sub-microparticles is 600-750 nm, the weight ratio of positively charged polymer to negatively charged polymer is 2,6: 1-3.8: 1, and the weight ratio of polymer/cannabinoids is 100:1 to 1:100, where the cannabinoids are arranged in hydrophobic patches formed between the positively charged polymer and the negatively charged polymer chains. The method of production of such a composition and its nutraceutical, pharmaceutical and cosmetic uses are also contemplated.
Multilayer coating for covering implants
PCT/ES2021/070830
A multilayer coating for coating a surface of an implant, the multilayer coating comprising polyelectrolyte layers, wherein the polyelectrolyte layers are interlayers of a layer comprising hyaluronic acid and/or derivatives thereof and a layer comprising chitosan and/or derivatives thereof and the multilayer coating having an outer surface with a contact angle of between 10o and 50o. A method for coating an implant with a multilayer coating, the method being a layer-by-layer coating method, comprising a first stage of activating a surface of the implant to be coated by surface hydroxyl, carboxylate, aldehyde, epoxide, isothiocyanate, amine, halide or thiol groups, a second stage of generating the multilayer coating by depositing intercalated polyelectrolyte layers of a layer comprising hyaluronic acid and/or its derivatives and a layer comprising chitosan and/or its derivatives on the activated surface to be coated, and a third stage of drying the multilayer coating, the resulting multilayer coating having an outer surface with a contact angle of between 10o and 50o /
Cationic Nanogels for Biotechnological Applications
WO 2011/113989 A1
The present invention is directed to a biocompatible cationic nanogel comprising a polymeric network, said polymeric network comprising polymeric units interconnected with each other through a crosslinking agent, wherein said polymeric network is obtainable by polymerisation in a dispersed medium of N-vinylcaprolactam and a crosslinking agent, in the presence of a cationic initiator and cationic or non-ionic emulsifier. The invention is also directed to procedures for obtaining the aforementioned nanogels as well as to pharmaceutical compositions comprising them.
Controlled release of soluble phytocannabinoid formulations
In aqueous media, methods and uses
WO 2021/156291 A1
The present invention relates to a controlled release system of phytocannabinoid formulation soluble in aqueous media comprising phytocannabinoids, or derivatives thereof, a non-ionic surfactant and a crosslinked polymer, wherein the pH of the compositions ranges from 4 to 9, and wherein the weight ratio of cannabinoid to hyaluronic acid is 50: 1 to 1:50, and the weight ratio of cannabinoid/non-ionic surfactant is from 1:30 to 1:1. The invention also relates to methods for producing the controlled release system of the aqueous soluble cannabinoid formulation and its pharmaceutical, cosmetic and nutraceutical applications. The methods of the present invention allow the crosslinking of hyaluronic acid containing encapsulated or vehicleised phytocannabinoids at neutral pH, avoiding degradation of the phytocannabinoids and preserving their functionality.
Coming soon: In the process of registration
PCT/EP2021/083550
Biocompatible microgels comprise a polymeric network, where the polymeric network consists of monomeric units interconnected with each other by means of a crosslinking agent. Such a polymeric network may be obtained by polymerisation in a dispersed medium of a biocompatible vinyl monomer and a crosslinking agent. The microgel may also include biologically active agents. Biocompatible microgels can be used, among other applications, for the transport and dosage of biologically active agents.