Research and development projects
Projects carried out
i+Med is a research company
Made up of researchers with a firm commitment to the development and constant improvement of our products. The development of new technologies allows i+Med to remain at the forefront of technology, constantly developing new products and inventions to solve challenges.
Project progress
Pipeline of innovations and completed projects.
Research programs
Find out about our latest ongoing research.
Our patents
We have 5 patents in different fields.
In-depth knowledge of the physical-chemical properties of materials allows the design of the most adapted product to each need.
Project progress
Only from a deep knowledge and a constant concern to challenge the properties of hydrogels a product of the highest quality can be obtained.
Nanocarriers
| Project | Description | Format | Therapeutic Area | Status |
| Daydrop Lipids | Sterile ophthalmic solution moisturizing and lubricating lipid-based. | Eye drops | Ophthalmology |  |
| Nuclencap | Particle formation by nucleation with high encapsulation efficiency and low excipient content. | General medicine | |
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| HyPhoCarrier | Vehiculization of hydrophobic substances in water-soluble nanoparticles. | Traumatology |  |
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| ONAK | Sustainable toothpaste tablets for oral hygiene. | Tablets | Oral hygiene | |
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Nanohydrogels
| Project | Description | Format | Therapeutic Area | Status |
| Fasnagel | Therapeutic nanohydrogels for the treatment of acute postoperative pain and the prevention of chronic pain. | Traumatology | |
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Hydrogels
| Project | Description | Format | Therapeutic Area | Status |
| Naumed | Gold nanoparticles based on hydrogel, for regeneration, radiotherapy, hyperthermia | Dermatology |  |
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| SECRET | Proof of concept of regenerative injectable product based on stem cell secretome. | Traumatology | |
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| ULTRACROSS | High durability biocompatible hydrogel for sustained long-term release of active substances. | Aesthetics / dermatology | |
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| DayDrop Advanced |
Sterile ophthalmic solution moisturizing and lubricating based on gamma poly (glutamic acid) and hyaluronic acid. | Eye drops | Ophthalmology | |
| ZKARE | Biopolymeric hydrogel for the treatment of chronic, very exhudative wounds. | Topical use | |
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| Sibari Republic | Línea cosmeceútica de cuidado facial antiedad a base de ácido hialurónico que fills wrinkles from the inside and moisturizes the skin in depth. |
Dermocosmetic
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Aesthetics |  |
| Sibari Republic FIRMNESS |
Cosmeceutical line of anti-aging facial care based on collagen with firming function. | |
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| Thermogel | Vehiculization and controlled otic release of a new therapeutic molecule using a biocompatible polymer. | Injectable | Oncology |  |
| OpHLINE | Viscoelastic solution of hyaluronic acid of high molecular weight obtained by biofermentation. | Injectable | Ophthalmology |  |
| TrHLINE | Viscoelastic solution of hyaluronic acid of high molecular weight obtained by biofermentation, intended for intra-articular injection. | Injectable | Traumatology | |
| TrHCROSS | Sterile viscoelastic solution of cross-linked hyaluronic acid indicated as an intra-articular viscoelastic supplement for the treatment of osteoarthritis. | Injectable | Traumatology | |
| BtHLINE | Biocompatible polymer solution of hyaluronic acid of high molecular weight obtained by biofermentation for aesthetic purposes. | Injectable | Aesthetics | |
| BtHCROSS | Biocompatible hydrogel of cross-linked hyaluronic acid obtained by biofermentation for aesthetic purposes. | Injectable | Aesthetics | |
| DayDrop | Sterile ophthalmic solution moisturizing and lubricating based on ectoin, hyaluronic acid and carboxymethylcellulose. | Eye drops | Ophthalmology | |
| BuddyDrop | Sterile, moisturizing and long-lasting lubricant solution that provides prolonged eye hydration. | Eye drops | Veterinary | |
| Profilm Aftas | Hydrogel supplemented with natural extracts that forms a protective film that relieves the first symptoms of canker sores. | Applicator spatula | Topical use | |
| Profilm Herpes | Hydrogel supplemented with natural extracts that forms a protective film that relieves the first symptoms of cold sores. | Airless | Topical Use | |
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Control release
| Project | Description | Format | Therapeutic Area | Status |
| Hydroen | Encapsulation of hydrophilic active ingredients in vehicular systems for sustained release. | Dermatology / aesthetics | |
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| AskeFAST | Hydrogel of defined durability for the immediate release of active ingredients focused on anatomical structure. | Injectable | Oncology | |
| BZBarren | Thermoeversible gel with local release of active substances for the treatment of gastreointestinal diseases. | Application Syringe | Surgery | |
| ControGel | Sterile lipid-based moisturizing and lubricating ophthalmic solution. | Injectable | Dermatology / Aesthetics | |
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Coating
| Project | Description | Format | Therapeutic Area | Status |
| Hydrocoat | Biodegradable coatings capable of loading and releasing antibiotic substances in a controlled manner in pacemakers. | Cardiology | |
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Others
| Project | Description | Format | Therapeutic Area | Status |
| nHAp/BIO3D | Biomimetic nanohydroxyapatite (nHAp) for integration into bioinks for tooth tissue regeneration. | 3D Printing | Dentistry | |
| MACROMA | Analysis of biological macromolecules by high efficiency liquid chromatography techniques and fluorescence techniques | Biomedicine | Analytics | |
| Ultra Absorption | Cosmeceutical line for irritated skin using CBD micelles improving deep absorption of the skin. | Encapsulation | Dermatologic | |
i+Med’s commitment is to generate new treatments and new products aimed at improving people’s quality of life.
Research programmes
i+Med actively participates in international research consortia with teams from universities and specialised companies to innovate in the field of smart nanotechnologies around biomaterials for the controlled release of active substances.
Current projects
| Year | Call | Entity | Title | Summary |
| 2022-2023 | INNOBIDEAK-INNOKONEXIO |
SPRI-Agencia Vasca de Desarrollo Empresarial |
Innokonexio INK-0012-2022 |
R&D&I valorization of CBD vehiculization |
| 2021-2023 | BIKAINTEK | Gobierno Vasco | ANTIBAU 018-B1/2021 | Incorporation of PhD |
| 2022-2024 | BIKAINTEK | Gobierno Vasco | CARTIGEL 024-B1/2022 | Incorporation of PhD |
| 2022-2026 | BIKAINTEK | Gobierno Vasco | RETINGEL 011-B2/2022 | Industrial PhD |
| 2022-2023 | ALAVA INNOVA | Diputación Foral de Álava | NARINA INNOEM-2022/00097 | New aseptic solutions for allergic rhinitis. |
| 2022-2024 | HAZITEK | Gobierno Vasco | HANTURA ZE-2022/00012 | Development of new diagnostic systems and pharmaceutical therapies for the treatment of Inflammatory Bowel Disease (IBD). |
| 2021-2024 | Torres Quevedo | MICINN | NAUSEN – PTQ2020-011076 | Gold nanoparticle-based sensors integrated into bioelectronic devices for the treatment of chronic wounds |
| 2020-2024 | Doctorado Industrial | MICINN | INYEGEL-DIN2019-010868 |
Introduction of functional gels in the manufacturing process of injectable biomedical products |
| 2020-2024 | Torres Quevedo | MICINN | HAPAFLUD-PTQ2019-010581 |
Improvement of production processes of nanostructured material in bio-integrating medical devices |
| 2020-2024 | H2020-MSCA-RISE-2019 | European Commission | MEDIPOL-871650 | Molecular Design of Polymers for Biomedical Applications |
para diferentes áreas terapéuticas
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2022
| Year | Call | Entity | Title | Summary |
| 2022 | HAZITEK | Gobierno Vasco |
NANOINJEK ZL-2022/00165 |
New smart nanoinjectables for repair of nerve tissue and other complex structures |
| 2021-2022 | HAZITEK | Gobierno Vasco | NAuMed ZL-2022/00117 ZL-2021/00514 |
New gold nanoparticle-based nanomaterials with biomedical applications |
| 2021-2022 | BIKAINTEK | Gobierno Vasco |
NAuMed 019-B1/2021 |
Incorporation of PhD |
| 2019-2022 |
INNOGLOBAL |
CDTI |
GAMMAREGEN INNO-20182003 |
Innovative new ingredient for medical device development: long-lasting ophthalmic eye drop |
| 2018-2022 |
BIKAINTEK |
Gobierno Vasco |
REFDEC-DI 01-AF-W2-2018-00002 |
Industrial PhD |
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2021
| Year | Call | Entity | Title | Summary |
| 2019-2021 | CERVERA | CDTI | HAPAZUR IDI-20190568 | New nanohydroxyapatite-based nanostructured vehicles for bio-regenerative applications |
| 2019- 2021 | HAZITEK | Gobierno Vasco | HAPAZUR – ZL2019/00548 ZL2020/00461 ZL2021/00283 |
New nanohydroxyapatite-based nanostructured vehicles for bio-regenerative applications |
| 2019-2021 | HAZITEK | Gobierno Vasco | IMABI ZE-2019/00012 |
Research in biofunctional materials for biomedical devices |
| 2021 | ALAVA INNOVA | Diputación Foral de Álava | BEGISOL INNOEM-2021/00037 | Innovation in aseptic filling process for multi-dose ophthalmic solutions |
| 2019-2021 | Doctorado Industrial | MICINN |
nHAp Recubrimientos DI-17-09668 |
Industrial PhD |
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2020
| Year | Call | Entity | Title | Summary |
| 2018-2020 | BIKAINTEK | Gobierno Vasco | NanHyDAD 01-AF-W1-2018-00007 | Incorporation of PhD |
| 2018-2020 | HAZITEK | Gobierno Vasco |
NanHyDAD ZL-2018/0353 ZL-2019/00054 |
Development of a new nanostructured biopolymeric device for the storage and controlled release of highly addictive analgesics. |
| 2020 | ALAVA INNOVA | Diputación Foral de Álava | DAYTANTA-INNOEM-2020/00089 | Innovation in aseptic manufacturing process for ophthalmic eye drops |
| 2018-2020 |
H2020-MSCA-IF-2017 |
European Commission | TherGelFas |
Novel nanometrically structured therapeutic hydrogel as injectable intended for preventive treatment of chronic pain |
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2019
| Year | Call | Entity | Title | Summary |
| 2019 | Álava Innova | Diputación Foral de Álava | ESTALTI INNOEM-2019/00056 | Innovation in bioactive coatings for biomedical titanium products |
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2018
| Year | Call | Entity | Title | Summary |
| 2017-2018 | HAZITEK | Gobierno Vasco | PRODITRA ZE-2017/00036 | New advanced biomedical products for diagnosis and treatment of diseases. |
| 2018 | ALAVA INNOVA | Diputación Foral de Álava |
NanHyDAD INNOEM-2018/00107 |
New injectable drug vehicle for the treatment of acute post-operative pain and the prevention of its chronification. |
| 2018 | H2020-SMEInst-2018-2020-1 | European Commission | FasNaGel | Novel therapeutic injectable for pain treatment |
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2017
| Year | Call | Entity | Title | Summary |
| 2017 | ALAVA INNOVA | Diputación Foral de Álava | CUSTODHYAL 865/17 | Nano-Hydrogel loaded with highly addictive drug. |
| 2017 | HAZITEK | Gobierno Vasco | NANOESTRUCTURAS VEHICULIZANTES DE MOLÉCULAS ACTIVAS ZL-2017/00125 | Biodegradable nanostructures as an alternative vehicle for the delivery of highly addictive drugs. |
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2016
| Year | Call | Entity | Title | Summary |
| 2016 | EUROPEO | CEE | EURONANOMED | Pilot plant fabrication of polymeric nanostructures for bone reconstruction. |
| 2016 | BIOEF | Servicio Vasco de Salud Osakidetza | TRANSPORTADOR NANOMÉTRICO | The idea is to be able to administer the tranexamic acid and the anaesthetic via a gel that would be administered into the surgical wound before suturing in order to avoid punctures, achieving a controlled release of the drugs and a localised diffusion to the area of interest. |
| 2016 | HAZITEK | Gobierno Vasco | HIRUGEL 2 ZL-2016/00083 | Cross-linked nanohydrogel acting as a vehicle for the controlled release of active agents. |
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2015
| Year | Call | Entity | Title | Summary |
| 2015 | INNOVA | Ayuntamiento de Vitoria-Gasteiz | Esterilización de Nanohidrogeles 2015/SUB0003 | Development and innovation in the new sterilisation process for the manufacture of nanohydrogels for controlled drug release. |
| 2015 | NEOTEC | CDTI MINECO | Nanohidrogeles Inteligentes SNEO-20151219 | Nanohydrogels for the controlled release of drugs, vitamins, growth factors and other compounds of interest. Within its business objectives it aims to develop new production methods taking advantage of technical advances to reach a profitable production level. |
| 2015 | GAITEK | Gobierno Vasco | HIRUGEL IG-2015/0000161 | Development and manufacture of injectable hydrogels, which can be implanted close to the area to be treated in a non-invasive way, and which release the drug in a controlled manner. The hydrogel will degrade and eventually be reabsorbed by the body. |
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2014
| Year | Call | Entity | Title | Summary |
| 2014 | INIZIA | Universidad del País Vasco UPV/ EHU |
NA+HA | Manufacture of HYALURONIC acid-based hydrogels as substitutes for organic fluids. |
Our patents
5 patents dedicated to controlled release
Our patents
Biocompatible microgels and their applications
PCT/EP2021/083550
Biocompatible microgels comprise a polymeric network, where the polymeric network consists of monomeric units interconnected with each other by means of a crosslinking agent. Such a polymeric network may be obtained by polymerisation in a dispersed medium of a biocompatible vinyl monomer and a crosslinking agent. The microgel may also include biologically active agents. Biocompatible microgels can be used, among other applications, for the transport and dosage of biologically active agents.
Composition from seawater and sub-microparticles with cannabinoids
In aqueous media, methods and uses
PCT/EP2021/083550
The present invention relates to a composition comprising cannabinoid-loaded polymeric sub-microparticles soluble in an aqueous medium comprising a polyelectrolyte complex comprising a positively charged polymer, selected from chitosan or a derivative thereof, a negatively charged polymer selected from hyaluronic acid or a derivative thereof, and a cannabinoid or a derivative thereof, or a mixture of cannabinoids or derivatives thereof, and water, wherein the size of the sub-microparticles is 600-750 nm, the weight ratio of positively charged polymer to negatively charged polymer is 2,6: 1-3.8: 1, and the weight ratio of polymer/cannabinoids is 100:1 to 1:100, where the cannabinoids are arranged in hydrophobic patches formed between the positively charged polymer and the negatively charged polymer chains. The method of production of such a composition and its nutraceutical, pharmaceutical and cosmetic uses are also contemplated.
Multilayer coating for covering implants
PCT/ES2021/070830
A multilayer coating for coating a surface of an implant, the multilayer coating comprising polyelectrolyte layers, wherein the polyelectrolyte layers are interlayers of a layer comprising hyaluronic acid and/or derivatives thereof and a layer comprising chitosan and/or derivatives thereof and the multilayer coating having an outer surface with a contact angle of between 10o and 50o. A method for coating an implant with a multilayer coating, the method being a layer-by-layer coating method, comprising a first stage of activating a surface of the implant to be coated by surface hydroxyl, carboxylate, aldehyde, epoxide, isothiocyanate, amine, halide or thiol groups, a second stage of generating the multilayer coating by depositing intercalated polyelectrolyte layers of a layer comprising hyaluronic acid and/or its derivatives and a layer comprising chitosan and/or its derivatives on the activated surface to be coated, and a third stage of drying the multilayer coating, the resulting multilayer coating having an outer surface with a contact angle of between 10o and 50o /
Cationic Nanogels for Biotechnological Applications
WO 2011/113989 A1
The present invention is directed to a biocompatible cationic nanogel comprising a polymeric network, said polymeric network comprising polymeric units interconnected with each other through a crosslinking agent, wherein said polymeric network is obtainable by polymerisation in a dispersed medium of N-vinylcaprolactam and a crosslinking agent, in the presence of a cationic initiator and cationic or non-ionic emulsifier. The invention is also directed to procedures for obtaining the aforementioned nanogels as well as to pharmaceutical compositions comprising them.
Controlled release of soluble phytocannabinoid formulations
In aqueous media, methods and uses
WO 2021/156291 A1
The present invention relates to a controlled release system of phytocannabinoid formulation soluble in aqueous media comprising phytocannabinoids, or derivatives thereof, a non-ionic surfactant and a crosslinked polymer, wherein the pH of the compositions ranges from 4 to 9, and wherein the weight ratio of cannabinoid to hyaluronic acid is 50: 1 to 1:50, and the weight ratio of cannabinoid/non-ionic surfactant is from 1:30 to 1:1. The invention also relates to methods for producing the controlled release system of the aqueous soluble cannabinoid formulation and its pharmaceutical, cosmetic and nutraceutical applications. The methods of the present invention allow the crosslinking of hyaluronic acid containing encapsulated or vehicleised phytocannabinoids at neutral pH, avoiding degradation of the phytocannabinoids and preserving their functionality.
Coming soon: In the process of registration
PCT/EP2021/083550
Biocompatible microgels comprise a polymeric network, where the polymeric network consists of monomeric units interconnected with each other by means of a crosslinking agent. Such a polymeric network may be obtained by polymerisation in a dispersed medium of a biocompatible vinyl monomer and a crosslinking agent. The microgel may also include biologically active agents. Biocompatible microgels can be used, among other applications, for the transport and dosage of biologically active agents.