Research and development projects

Projects carried out in 2022

i+Med is a research company

Made up of researchers with a firm commitment to the development and constant improvement of our products. The development of new technologies allows i+Med to remain at the forefront of technology, constantly developing new products and inventions to solve challenges.

 

Project progress

Pipeline of innovations and completed projects.

Research programs

Find out about our latest ongoing research.

Our patents

We have 5 patents in different fields.

In-depth knowledge of the physical-chemical properties of materials allows the design of the most adapted product to each need.

Project progress

Only from a deep knowledge and a constant concern to challenge the properties of hydrogels a product of the highest quality can be obtained.

Nanocarriers
Project Description  Format Therapeutic Area Status
Daydrop Lipids Sterile ophthalmic solution moisturizing and lubricating lipid-based. Eye drops Ophthalmology
Nuclencap Particle formation by nucleation with high encapsulation efficiency and low excipient content. General medicine
HyPhoCarrier Vehiculization of hydrophobic substances in water-soluble nanoparticles. Traumatology
ONAK Sustainable toothpaste tablets for oral hygiene. Tablets Oral hygiene

 

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Nanohydrogels
Project Description  Format Therapeutic Area Status
Fasnagel Therapeutic nanohydrogels for the treatment of acute postoperative pain and the prevention of chronic pain. Traumatology

 

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Hydrogels
Project Description  Format Therapeutic Area Status
Naumed Gold nanoparticles based on hydrogel, for regeneration, radiotherapy, hyperthermia Dermatology
SECRET Proof of concept of regenerative injectable product based on stem cell secretome. Traumatology
ULTRACROSS  High durability biocompatible hydrogel for sustained long-term release of active substances. Aesthetics / dermatology
DayDrop
Advanced
Sterile ophthalmic solution moisturizing and lubricating based on gamma poly (glutamic acid) and hyaluronic acid. Eye drops Ophthalmology
ZKARE Biopolymeric hydrogel for the treatment of chronic, very exhudative wounds. Topical use
Sibari Republic Línea cosmeceútica de cuidado facial antiedad a base de ácido hialurónico que fills wrinkles from the inside and moisturizes the skin in depth.

Dermocosmetic

 

Aesthetics
Sibari Republic
FIRMNESS
Cosmeceutical line of anti-aging facial care based on collagen with firming function.
Thermogel Vehiculization and controlled otic release of a new therapeutic molecule using a biocompatible polymer. Injectable Oncology
OpHLINE Viscoelastic solution of hyaluronic acid of high molecular weight obtained by biofermentation. Injectable Ophthalmology
TrHLINE Viscoelastic solution of hyaluronic acid of high molecular weight obtained by biofermentation, intended for intra-articular injection. Injectable Traumatology
TrHCROSS Sterile viscoelastic solution of cross-linked hyaluronic acid indicated as an intra-articular viscoelastic supplement for the treatment of osteoarthritis. Injectable Traumatology
BtHLINE Biocompatible polymer solution of hyaluronic acid of high molecular weight obtained by biofermentation for aesthetic purposes. Injectable Aesthetics
BtHCROSS Biocompatible hydrogel of cross-linked hyaluronic acid obtained by biofermentation for aesthetic purposes. Injectable Aesthetics
DayDrop Sterile ophthalmic solution moisturizing and lubricating based on ectoin, hyaluronic acid and carboxymethylcellulose. Eye drops Ophthalmology
BuddyDrop Sterile, moisturizing and long-lasting lubricant solution that provides prolonged eye hydration. Eye drops Veterinary
Profilm Aftas Hydrogel supplemented with natural extracts that forms a protective film that relieves the first symptoms of canker sores. Applicator spatula Topical use
Profilm Herpes Hydrogel supplemented with natural extracts that forms a protective film that relieves the first symptoms of cold sores. Airless Topical Use
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Control release
Project Description  Format Therapeutic Area Status
Hydroen Encapsulation of hydrophilic active ingredients in vehicular systems for sustained release. Dermatology / aesthetics
AskeFAST Hydrogel of defined durability for the immediate release of active ingredients focused on anatomical structure. Injectable Oncology
BZBarren Thermoeversible gel with local release of active substances for the treatment of gastreointestinal diseases. Application Syringe Surgery
ControGel Sterile lipid-based moisturizing and lubricating ophthalmic solution. Injectable Dermatology / Aesthetics
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Coating

 

Project Description  Format Therapeutic Area Status
Hydrocoat Biodegradable coatings capable of loading and releasing antibiotic substances in a controlled manner in pacemakers. Cardiology
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Otros
Project Description  Format Therapeutic Area Status
nHAp/BIO3D Biomimetic nanohydroxyapatite (nHAp) for integration into bioinks for tooth tissue regeneration. 3D Printing Dentistry
MACROMA Analysis of biological macromolecules by high efficiency liquid chromatography techniques and fluorescence techniques Biomedicine Analytics
Ultra Absorption Cosmeceutical line for irritated skin using CBD micelles improving deep absorption of the skin. Encapsulation Dermatologic

 

i+Med’s commitment is to generate new treatments and new products aimed at improving people’s quality of life.

Research programmes

i+Med actively participates in international research consortia with teams from universities and specialised companies to innovate in the field of smart nanotechnologies around biomaterials for the controlled release of active substances.

Current projects
Year Announcement Entity Title Sumary
2021-2024 Torres Quevedo  NAUSEN – PTQ2020-011076 Gold nanoparticle-based sensors integrated into bioelectronic devices for the treatment of chronic wounds
2020-2024 Doctorado Industrial INYEGEL-DIN2019-010868 Introduction of functional gels in injectable biomedical manufacturing processes
Torres Quevedo HAPAFLUD-PTQ2019-010581 Improving the production processes of nanostructured materials in bio-integrating medical devices.
2019-2023 H2020-MSCA-RISE-2019 MEDIPOL-871650 Molecular Design of Polymers for Biomedical Applications
2019-2023 Doctorado Industrial nHAp Recubrimientos DI-17-09668 Industrial PHD
INNOGLOBAL GAMMAREGEN – INNO-20182003 Innovative new ingredient for medical device development: long-lasting ophthalmic eye drop
2021-2022
BIKAINTEK NAuMed 019-B1/2021 Incorporation of Doctor

para diferentes áreas terapéuticas

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2021
Year Announcement Entity Title Summary
2021-2024 Torres Quevedo  NAUSEN – PTQ2020-011076 Gold nanoparticle-based sensors integrated into bioelectronic devices for the treatment of chronic wounds
2019-2021 CERVERA HAPAZUR IDI-20190568 New nanohydroxyapatite-based nanostructured vehicles for bio-regenerative applications
HAZITEK HAPAZUR – ZL-2019/00548 – ZL-2020/00461 – ZL-2021/00283 New nanohydroxyapatite-based nanostructured vehicles for bio-regenerative applications
2019-2021 HAZITEK-Consorcio IMABI Exp.ZE-2019/00012 Research on Biofunctional Materials for devices in the biomedical sector
2018-2021 BIKAINTEK REFDEC-DI 01-AF-W2-2018-00002 Industrial PhD
2021 HAZITEK NAuMed ZL-2021/00514 New nanomaterials based on gold nanoparticles with biomedical applications
2021 ALAVA INNOVA BEGISOL INNOEM-2021/00037 Innovation in aseptic filling process for multi-dose ophthalmic solutions
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2020
Year Announcement Entity Title Summary
2018-2020 BIKAINTEK ANTIBAU 018-B1/2021 Incorporation of Doctor
2018-2020 BIKAINTEK NanHyDAD 01-AF-W1-2018-00007 Incorporation of Doctor
2018-2020 HAZITEK NanHyDAD ZL-2018/0353 ZL-2019/00054 Development of a new nanostructured biopolymeric device for the storage and controlled release of highly addictive analgesics.
ALAVA INNOVA DAYTANTA-INNOEM-2020/00089 Innovation in aseptic manufacturing process for ophthalmic eye drops
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2019
Year Announcement Entity Title Summary
2019 Álava Innova ESTALTI INNOEM-2019/0056 Innovation in bioactive coatings for biomedical titanium products
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2018
Year Annoucenment  Entity Title Summary
2017-2018 HAZITEK PRODITRA EXP. ZE-217/00036 New advanced biomedical products for diagnosis and treatment of diseases.
2018 H2020-MSCA-IF-2017 TherGelFas Novel nanometrically structured therapeutic hydrogel as injectable intended for preventive treatment of chronic pain.
2018 ALAVA INNOVA NanHyDAD New injectable drug vehicle for the treatment of acute post-operative pain and the prevention of its chronification.
2018 H2020-SMEInst-2018-2020-1 FasNaGel Novel therapeutic injectable for pain treatment
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2017
Year Annoucement  Entity Title Summary
2017 ALAVA INNOVA CUSTODHYAL Nano-Hydrogel loaded with highly addictive drug.
2017 HAZITEK NANOESTRUCTURAS VEHICULIZANTES DE MOLÉCULAS ACTIVAS Biodegradable nanostructures as an alternative vehicle for the delivery of highly addictive drugs.
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2016
Year Annoucement  Entity Title Summary
2016 EUROPEO CEE EURONANOMED Pilot plant fabrication of polymeric nanostructures for bone reconstruction.
2016 BIOEF TRANSPORTADOR NANOMÉTRICO The idea is to be able to administer the tranexamic acid and the anaesthetic via a gel that would be administered into the surgical wound before suturing in order to avoid punctures, achieving a controlled release of the drugs and a localised diffusion to the area of interest.
2016 HAZITEK HIRUGEL 2 Cross-linked nanohydrogel acting as a vehicle for the controlled release of active agents.
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2015
 
Year Annoucement  Entity Title Summary
2015 INNOVA Esterilización de Nanohidrogeles Development and innovation in the new sterilisation process for the manufacture of nanohydrogels for controlled drug release.
NEOTEC Nanohidrogeles Inteligentes Nanohydrogels for the controlled release of drugs, vitamins, growth factors and other compounds of interest. Within its business objectives it aims to develop new production methods taking advantage of technical advances to reach a profitable production level.
GAITEK HIRUGEL Development and manufacture of injectable hydrogels, which can be implanted close to the area to be treated in a non-invasive way, and which release the drug in a controlled manner. The hydrogel will degrade and eventually be reabsorbed by the body.
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2014

mm

Year Annoucement  Entity Title Summary
2014 INIZIA NA+HA Manufacture of HYALURONIC acid-based hydrogels as substitutes for organic fluids.

Our patents

5 patents dedicated to controlled release

Our patents

Biocompatible microgels and their applications

PCT/EP2021/083550

Biocompatible microgels comprise a polymeric network, where the polymeric network consists of monomeric units interconnected with each other by means of a crosslinking agent. Such a polymeric network may be obtained by polymerisation in a dispersed medium of a biocompatible vinyl monomer and a crosslinking agent. The microgel may also include biologically active agents. Biocompatible microgels can be used, among other applications, for the transport and dosage of biologically active agents.

Composition from seawater and sub-microparticles with cannabinoids

In aqueous media, methods and uses

PCT/EP2021/083550

The present invention relates to a composition comprising cannabinoid-loaded polymeric sub-microparticles soluble in an aqueous medium comprising a polyelectrolyte complex comprising a positively charged polymer, selected from chitosan or a derivative thereof, a negatively charged polymer selected from hyaluronic acid or a derivative thereof, and a cannabinoid or a derivative thereof, or a mixture of cannabinoids or derivatives thereof, and water, wherein the size of the sub-microparticles is 600-750 nm, the weight ratio of positively charged polymer to negatively charged polymer is 2,6: 1-3.8: 1, and the weight ratio of polymer/cannabinoids is 100:1 to 1:100, where the cannabinoids are arranged in hydrophobic patches formed between the positively charged polymer and the negatively charged polymer chains. The method of production of such a composition and its nutraceutical, pharmaceutical and cosmetic uses are also contemplated. 

Multilayer coating for covering implants

PCT/ES2021/070830

A multilayer coating for coating a surface of an implant, the multilayer coating comprising polyelectrolyte layers, wherein the polyelectrolyte layers are interlayers of a layer comprising hyaluronic acid and/or derivatives thereof and a layer comprising chitosan and/or derivatives thereof and the multilayer coating having an outer surface with a contact angle of between 10o and 50o. A method for coating an implant with a multilayer coating, the method being a layer-by-layer coating method, comprising a first stage of activating a surface of the implant to be coated by surface hydroxyl, carboxylate, aldehyde, epoxide, isothiocyanate, amine, halide or thiol groups, a second stage of generating the multilayer coating by depositing intercalated polyelectrolyte layers of a layer comprising hyaluronic acid and/or its derivatives and a layer comprising chitosan and/or its derivatives on the activated surface to be coated, and a third stage of drying the multilayer coating, the resulting multilayer coating having an outer surface with a contact angle of between 10o and 50o / 

Cationic Nanogels for Biotechnological Applications

WO 2011/113989 A1

The present invention is directed to a biocompatible cationic nanogel comprising a polymeric network, said polymeric network comprising polymeric units interconnected with each other through a crosslinking agent, wherein said polymeric network is obtainable by polymerisation in a dispersed medium of N-vinylcaprolactam and a crosslinking agent, in the presence of a cationic initiator and cationic or non-ionic emulsifier. The invention is also directed to procedures for obtaining the aforementioned nanogels as well as to pharmaceutical compositions comprising them.

Controlled release of soluble phytocannabinoid formulations

In aqueous media, methods and uses

WO 2021/156291 A1

The present invention relates to a controlled release system of phytocannabinoid formulation soluble in aqueous media comprising phytocannabinoids, or derivatives thereof, a non-ionic surfactant and a crosslinked polymer, wherein the pH of the compositions ranges from 4 to 9, and wherein the weight ratio of cannabinoid to hyaluronic acid is 50: 1 to 1:50, and the weight ratio of cannabinoid/non-ionic surfactant is from 1:30 to 1:1. The invention also relates to methods for producing the controlled release system of the aqueous soluble cannabinoid formulation and its pharmaceutical, cosmetic and nutraceutical applications. The methods of the present invention allow the crosslinking of hyaluronic acid containing encapsulated or vehicleised phytocannabinoids at neutral pH, avoiding degradation of the phytocannabinoids and preserving their functionality.

 

Coming soon: In the process of registration

PCT/EP2021/083550

Biocompatible microgels comprise a polymeric network, where the polymeric network consists of monomeric units interconnected with each other by means of a crosslinking agent. Such a polymeric network may be obtained by polymerisation in a dispersed medium of a biocompatible vinyl monomer and a crosslinking agent. The microgel may also include biologically active agents. Biocompatible microgels can be used, among other applications, for the transport and dosage of biologically active agents.